Metoclopramide

From Academic Kids

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Metoclopramide.png
Chemical structure of metoclopramide

Metoclopramide is a parasympathomimetic, and is also a potent dopamine antagonist that enters the central nervous system. It is used for gastric emptying in patients with gastric motor failure (gastroparesis).

It is also useful for facilitating small bowel intubation and as an antiemetic. The most common side effects are somnolence, nervousness, and dystonic reactions.

The Food and Drug Administration advises: "Tardive Dyskinesia, a syndrome consisting of potentially irreversible, dyskinetic movements may develop in patients treated with metoclopramide...Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase with the duration of treatment and the total cumulative dose." As with any medication, you should discuss all potential benefits, potential risks, and potential side effects with your physician.

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Metoclopramide_ampule.jpg
Plastic ampule of metoclopramide.

It is available under trade names such as Apo-Metoclop (Apotex), Maxeran (Hoechst Marion Roussel), Nu-Metoclopramide (Nu-Pharm), Maxolon (DermaTech), and Reglan (Weyth-Ayerst).

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